Overweight and obesity significantly reduce pregnancy, implantation, and live birth rates in women undergoing In Vitro Fertilization procedures.

OBJECTIVE: The objective of this study was to evaluate the effects of overweight and obesity on fertility outcomes in IVF procedures. METHODS: This was a retrospective and nonrandomized study that included 191 IVF/ICSI cycles using non-donor oocytes performed between July 2016 and December 2018 that were allocated according to Body Mass Index (BMI) in three groups: Normal group: 18.5-24.9 (n=67 women), Overweight group: 25.0-29.9 (n=86 women) and Obesity group: ≥30.0 (n=38 women). We compared fertilization rates, embryo quality at day 3, development and quality of blastocyst, pregnancy rates, implantation rates, and live birth rates. RESULTS: Patients from all groups had similar stimulation days, but those women with overweight and obesity used more hormones compared to women with normal weight (p<0.05). Fertilization rates, zygotes that underwent cleavage and good-quality embryos at Day 3 were similar between the three evaluated groups. The groups of overweight and obesity had embryos at Day 3 with significantly less cells, compared to those from the normal group (p<0.05). The blastocyst development rate was significantly lower in women with overweight and obesity compared to women with normal BMI (p<0.05); but, the percentages of good blastocysts were similar in all studied patients. Pregnancy, implantation and live birth rates were significantly lower in the group of women with overweight and obesity, compared to those women with normal weight (p<0.05). Obese women had significantly more miscarriages compared to those in the other groups (p<0.05). CONCLUSIONS: Our data shows that an increased BMI affects embryo development and significantly reduces the pregnancy, implantation and live birth rates.

Tasa de Blastulación en función del número de ovocitos en metafase II / The Percentage of Blastulation as function in the number of metaphase II oocytes

OBJETIVOS: Determinar el número de ovocitos en metafase II que se necesitan para lograr una óptima tasa de blastulación y conseguir una mejor tasa de gestación. DISEÑO: Estudio Retrospectivo. Institución: Unidad de Fertilidad -Hospital Alcivar Guayaquil (Ecuador). PARTICIPANTES: Mujeres con diagnóstico de infertilidad. INTERVENCIONES: Fueron 110 Mujeres en las que se les realizo FIV-ICSI, excluyendo transferencia día 3 y ciclos cancelados. previa estimulación ovárica controlada, El cultivo continúa a blastocistos. Principales medidas de resultados: Tasa de ovocitos en metafase II, Tasa de embarazo. Edad Promedio de las pacientes, Técnica FIV-ICSI. RESULTADOS: Edad promedio de las pacientes 33,41. Técnica FIV: 73 pacientes 66,4 % ICSI: 37 pacientes 33,6 %. Embarazo: Si Gestación: 57,3 %, No gestación: 42,7 %. Tasa de Ovocitos en Metafase II: Una Media de 7,5. CONCLUSIÓN: La tasa de gestación que coincide con los resultados del centro (50 a 60 %), la alcanzamos a partir de 7 ovocitos maduros. La tasa de blastulacion promedio fue de 39,2 %

OBJECTIVES: Determine the number of metaphase II oocytes that are needed for optimum rate blastulation and get a better rate of gestation. DESIGN: Retrospective study. Institution: Fertility Unit -Hospital Alcivar Guayaquil (Ecuador). PARTICIPANTS: Women diagnosed with infertility. INTERVENTIONS: There were 110 women in which they are performed IVF-ICSI, excluding 3rd and transfer canceled cycles. After controlled ovarian stimulation, cultivation continues to blastocysts. Main outcome measures: Rate of metaphase II oocytes, pregnancy rate. Average age of patients, IVF-ICSI technique. RESULTS: Mean age of the patients 33,41. IVF technique: 66.4% ICSI 73 patients: 37 patients 33.6%. Pregnancy: If pregnancy: 57.3% No pregnancy: 42.7% .Tasa of oocytes in metaphase II: A Media 7.5. CONCLUSION: The pregnancy rate coincides with the center's results (50-60%), the reach from 7 mature oocytes. The average rate was 39.2% blastulation

Percentage of Blastulation on the Number and Function of Metaphase II Oocytes.

OBJECTIVE: Establish the number of metaphase II oocytes that are needed for optimum blastulation rate and to achieve a better rate of gestation. METHODS: Retrospective study. Women diagnosed with infertility. There were 110 women submitted to IVF/ICSI, excluding third day transfers and those with canceled cycles. After controlled ovarian stimulation, cultivation continued to blastocysts. RESULTS: Average age of the patients: 33.41. IVF technique: 73 patients, 66.4%; ICSI: 37 patients, 33.6%. Pregnancy: gestation: 57.3%; Non-gestation: 42.7%. Mean number of oocytes in metaphase II: 7.5. CONCLUSION: The gestation rate coincides with the center's results (50-60%), reached with 7 mature oocytes. Mean blastulation rate was 39.2%.